This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
GRK2 Antibodies
AND GRK2 ELISA kits, GRK2 Proteins
Many biological assays use antibodies to detect GRK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRK2 antibodies...
Designing a Western blot for GRK2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GRK2 Western Blot GuideGRK2 Infographic by Boster Bio
All GRK2 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # A32388-1
100 μg/vial
Cat # A32388-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01473-1
100 μg/vial
Cat # A01473-1
100 μg/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2602
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2602
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2073
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2073
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1252
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1252
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1696
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1696
1 kit, containing one 96-well plate and all necessary reagents
GRK2 Overview
Facts about Beta-adrenergic receptor kinase 1.
Beta-adrenergic receptor kinase 1 (GRK2)
Specifically phosphorylates the agonist-occupied kind of the beta-adrenergic and closely related receptors, probably causing a desensitization of those. Key regulator of LPAR1 signaling.
Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378).
Gene Information
| Human | |
|---|---|
| Gene Name: | GRK2 |
| Uniprot: | P25098 |
| Entrez: | 156 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
ADRBK1; adrenergic, beta, receptor kinase 1; BARK; BARK1; BARK1beta-ARK-1; Beta-ARK1; Beta-ARK-1; EC 2.7.11; EC 2.7.11.15; FLJ16718; G-protein coupled receptor kinase 2; GRK2; GRK2beta-adrenergic receptor kinase 1
Molecular Weight
Mass (kDA):
79.574 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.2 |
| Sequence: | 11; NC_000011.10 (67266420..67286556) |
Tissue Specificity
Expressed in peripheral blood leukocytes.
Subcellular Localizations
Cytoplasm. Cell membrane.
Diseases
- Heart Failure
- Hypertensive Disease
- Inflammation
- Infarction
- Myocardial Infarction
- Hypertrophy
- Pertussis
- Ischemia
- Neoplasms
- Diabetes Mellitus
- Pain
- Cardiac Failure Chronic
- Nervousness
Interacting Proteins
- FPR1
- GIT1
- GRK3
- MDM2
- NFKBIA
- PTCH1
- UBC
Pathways
- Receptor Internalization
- Pathogenesis
- Localization
- Endocytosis
- Chemotaxis
- Transport
- Aging
- Cell Proliferation
- Secretion
- Vasoconstriction
- Bioluminescence
- Cell Migration
- Excretion
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Nitrosylation
- Reduction
Research Areas
- Cancer
- Cellular Markers
- Mitochondrial Markers
- Neuroscience
- Protein Kinase
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRK2
bosterbio.com/bosterbio-gene-info-cards/GRK2
References
PMID: 2037065 by Benovic J.L., et al. cDNA cloning and chromosomal localization of the human beta- adrenergic receptor kinase.
PMID: 1339451 by Chuang T.T., et al. High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation.